Spedding Research Solutions SAS

Our Research

Our Research :

-          Stress and neuroplasticity, depression and schizophrenia

-          Neuroinflammation in the brain changes the paradigm

-          From Depression to Alzheimer’s.

-          A breakthrough in Amyotrophic Lateral Sclerosis (ALS, Motoneurone Disease), and metabolism
Two grants on this subject...

-          Sarcopenia, sport, muscle and nerve.

-          The recent evolutionary (and epigenetic) changes  that allowed the evolution of running, human   metabolism and brain.

How about this for a molecular antagonism of stress  ! 

Corticosterone directly increases AMPA receptor mobility and reduces dwell time in hippocampal
synapses, whereas the antidepressant tianeptine increases dwell time in the synapse, antagonising the effects of  corticosterone on AMPA receptor mobility - and on long term potentiation, a molecular measure of memory.
This was a result of a collaboration between Jerry Lambert's group in Dundee and Daniel Choquet/Laurent Groc's group in Bordeaux.

Link to publication :

Zhang H, Etherington LA, Hafner AS, Belelli D, Coussen F, Delagrange P, Chaouloff F, Spedding M, Lambert JJ, Choquet D, Groc L  Regulation of AMPA receptor surface trafficking and synaptic plasticity by a cognitive enhancer and antidepressant molecule. Mol Psychiatry. 2013 Apr;18(4):471-84 

 

 

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